Search results for " cD [Galaxies]"

showing 4 items of 4 documents

Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes

2021

Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…

DU145 tumor cellsCachannelPrimary alcohol01 natural sciencesAminoethylcyclohexanes; Antagonistic activity; Biotransformation; Ca; 2+; influx assay; Calculated free energy of binding; CD spectroscopy; Chiral HPLC; DU145 tumor cells; Inhibition of human prostate tumor cell growth; Lipophilicity; Molecular dynamics simulations; Molecular interactions; per-residue binding free energy; Selectivity; Stereochemistry; Structure affinity relationships; Voltage gated Ca; 2+; channel; σ receptors; σ; 1; receptor affinityInhibition of human prostate tumor cell growthStereochemistryDrug DiscoveryMoietySelectivityBiotransformationσ receptor0303 health sciencesChemistryAminoethylcyclohexanesCD spectroscopyAbsolute configurationAminoethylcyclohexaneMolecular interactionGeneral MedicineAntagonistic activityper-residue binding free energyreceptor affinityLipophilicityVoltage gated CaStereochemistry12+Calculated free energy of bindingRetinal ganglion03 medical and health sciencesσMolecular dynamics simulationChiral HPLCLipophilicityMolecular interactionsStructure affinity relationship030304 developmental biologyPharmacologyDU145 tumor cellinflux assayMolecular dynamics simulations010405 organic chemistryOrganic ChemistryDiastereomer0104 chemical sciencesChiral column chromatographyσ receptorsStructure affinity relationshipsEnantiomerEuropean Journal of Medicinal Chemistry
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Spectroscopy of the neutron-deficient isobars 163 Re and 163 W using tagging techniques

2008

Bozok University;Erciyes University;et al.;Istanbul University;Nigde University;The Turkish Atomic Energy Authority (TAEK)

PhysicsNuclear Reactions 60 Ni+ 106 Cd at 270 MeV beam energy enriched targetsSpectrometerProtonYrastNuclear TheorySegmented Si and Ge detectorsNeutron spectroscopyNuclear physicsMeasured E ?IsobarNeutronGasfilled recoil separatorNuclear ExperimentGround stateRadioactive decay
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Decays of new nuclides and isomers beyond the proton drip line - The influence of neutron configurations

2008

Bozok University;Erciyes University;et al.;Istanbul University;Nigde University;The Turkish Atomic Energy Authority (TAEK)

PhysicsProtonGamma rayAlpha particleSegmented Si and Ge detectors. Measured E ? E proton E ? T 1/2Nuclear physicsNuclear Reactions 58 Ni+ 106 Cd at 290300310 MeV beam energyBeta particleNeutronEnriched targetsNuclideAlpha decayGas-filled recoil separatorAtomic physicsNuclear ExperimentGround state
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The CdCl2 effects on synthetic DNAs encaged in the nanodomains of a cationic water-in-oil microemulsion

2011

The present work is dedicated to the study of the interactions of CdCl(2) with the synthetic polynucleotides polyAT and polyGC confined in the nanoscopic aqueous compartment of the water-in-oil microemulsion CTAB/pentanol/hexane/water, with the goal to mimic in vitro the situation met by the nucleic acids in vivo. In biological structures, in fact, very long strings of nucleic acids are segregated into very small compartments having a radius exceedingly smaller than the length of the encapsulated macromolecule. For comparison, the behaviour of polyGC was also studied in aqueous solutions of matched composition. The conformational and thermal stabilities of both polynucleotides enclosed in t…

inorganic chemicalsnanodomaincadmiumPolynucleotideswater-in-oil microemulsion; cadmium; model polynucleotidesGeneral Physics and AstronomyDissociation (chemistry)model polynucleotideschemistry.chemical_compoundCadmium ChlorideHexanesOrganic chemistryMicroemulsionPhysical and Theoretical ChemistryAqueous solutionconformational transitionCetrimoniumChemistryCationic polymerizationWaterDNAHexaneUV and CD spectroscopiesreverse micelleChemical engineeringwater-in-oil microemulsionPolynucleotideCetrimonium CompoundsNucleic acidCationic w/o microemulsionEmulsionssynthetic polynucleotideOilsMacromolecule
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